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JAK/STAT SignalingStem Cell/Wnt-
Stattic ??????????????????STAT3????????????????????????????????????
相關(guān)產(chǎn)品
AG-490-NSC 74859-Cryptotanshinone-Napabucasin-WP1066-Homoharringtonine-Niclosamide-SH-4-54-AS1517499-Leflunomide-HO-3867-Alantolactone-BP-1-102-Corylifol A-Nifuroxazide-
生物活性
Description
Stattic is a potent inhibitor ofSTAT3, used for cancer treatment.
In Vitro
Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+and D44+/CD24+subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 ??M). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+and CD44+/CD24+subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+and CD44+/CD24+subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2].
References
