"目錄號: HY-14617
Paradol 是一種姜科植物中發(fā)現(xiàn)的刺激性酚類物質次伶。在小鼠皮膚癌變中钝凶，Paradol結合到環(huán)氧合酶 (COX-2) 活性位點颜阐，有效抑制腫瘤發(fā)展挖息。
相關產品
Celecoxib-Indomethacin-Acetaminophen-Aspirin-Ibuprofen-NS-398-Rofecoxib-Diclofenac Sodium-Iguratimod-Parecoxib-Sulindac-Etoricoxib-Naproxen-Valdecoxib-(-)-Epicatechin-
生物活性
Description
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds tocyclooxygenase (COX)-2active site.
IC50& Target
COX-2[1]
In Vitro
Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism[2].
In Vivo
Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge[3]. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study[4].
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