The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
SIRT1的降低通過組蛋白H3K9甲基轉(zhuǎn)移酶影響心肌梗死
Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection.?
心肌梗塞會(huì)削弱心臟功能并且?guī)?lái)巨大的健康風(fēng)險(xiǎn)关霸。已知的第三類脫乙酰酶SIRT具有心臟保護(hù)作用。
SIRT1 expression is downregulated in the heart by a number of stress stimuli that collectively drive the pathogenesis of MI, although the underlying mechanism remains largely obscure.?
SIRT1在心臟中的表達(dá)被多種應(yīng)激刺激下調(diào)，這些刺激共同驅(qū)動(dòng)心肌梗死的發(fā)病機(jī)制烛愧，盡管其潛在機(jī)制尚不清楚
Here we show that in primary rat neonatal ventricular myocytes (NRVMs), ischaemic or oxidative stress leads to a rapid upregulation of SUV39H, the mammalian histone H3K9 methyltransferase, paralleling SIRT1 downregulation.?
我們?cè)谶@里證明了桐筏，原代大鼠新生心室肌細(xì)胞中可婶，缺血或氧化應(yīng)激誘導(dǎo)哺乳動(dòng)物組蛋白H3K9甲基轉(zhuǎn)移酶SUV39H快速上調(diào)芍阎，同時(shí)伴隨SIRT1的下調(diào)
Compared to wild-type littermates, SUV39H knockout mice are protected from MI. Likewise, suppression of SUV39H activity with chaetocin attenuates cardiac injury following MI.?
與同窩出生的野生型小鼠相比燎斩，SUV39H敲除小鼠免于心肌梗死杯活。同樣的匆帚，用毛霉素抑制SUV39H的活性可減輕心肌梗死后的心臟損傷。
Mechanistically, SUV39H cooperates with heterochromatin protein 1 gamma (HP1g) to catalyse H3K9 trimethylation on the SIRT1 promoter and represses SIRT1 transcription.?
在機(jī)制上旁钧，SUV39H與異染色質(zhì)蛋白1γ協(xié)同催化SIRT1啟動(dòng)子上的H3K9三甲基化吸重，并抑制SIRT1轉(zhuǎn)錄
SUV39H augments intracellular ROS levels in a SIRT1-dependent manner. Our data identify a previously unrecognized role for SUV39H linking SIRT1 trans-repression to myocardial infarction.
SUV39H以SIRT依賴的方式增加了細(xì)胞內(nèi)的ROS水平，我們的數(shù)據(jù)確定了SUV39H和SIRT1反式抑制心肌梗死的新的機(jī)制歪今。
