IntAct
https://www.ebi.ac.uk/intact/
Orchard S, et al. (2013) The MIntAct project - IntAct as a common curation platform for 11 molecular interaction databases. Nucleic Acids Research, 42(Database issue):D358-63, 13 Nov 2013, PMID: 24234451: Abstract, Article
IntAct provides a free, open source database system and analysis tools for molecular interaction data. All interactions are derived from literature curation or direct user submissions.
Contains molecular reactions between gene, protein and chemical entities.
License
IntAct is an open source, open data resource, available to anyone. Usage of IntAct material is covered by two licenses:
The terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, meaning you are free to use, reproduce and adapt our data providing you give appropriate credit, apply to all IntAct data, e.g. PSI-MI XML, MI-JSON and MITAB files, as well as data directly accessed via web pages/services.
The terms of the Apache License, Version 2.0 apply to all software relating to the functionality of IntAct, derived websites and webservices, the Curator Tool, SQL and Graph Database data dumps, and Art and Branding Materials.
下載數(shù)據(jù)：
FTP： ftp://ftp.ebi.ac.uk/pub/databases/intact/current
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intact.txt.gz：一行為一條互作關(guān)系記錄，A-B interaction
具體說明見：intact文件列的說明.xls
| 標(biāo)題 | 解釋 | 例子 |
|---|---|---|
| #ID(s) interactor A | A的id | uniprotkb:P49418 |
| ID(s) interactor B | B的id | uniprotkb:O43426 |
| Alt. ID(s) interactor A | 其他數(shù)據(jù)庫來源的id | intact:EBI-7121510\ |
| Alt. ID(s) interactor B | 其他數(shù)據(jù)庫來源的id | intact:EBI-2821539\ |
| Alias(es) interactor A | 其他名字 | psi-mi:amph_human(display_long)\ |
| Alias(es) interactor B | 其他名字 | psi-mi:synj1_human(display_long)\ |
| Interaction detection method(s) | 互作檢測方法 | psi-mi:"MI:0084"(phage display) |
| Publication 1st author(s) | 發(fā)表的第一作者 | Cestra et al. (1999) |
| Publication Identifier(s) | pubmed medline | pubmed:10542231\ |
| Taxid interactor A | 10 A所屬物種 | taxid:9606(human)\ |
| Taxid interactor B | 11 B所屬物種 | taxid:9606(human)\ |
| Interaction type(s) | 12 互作的類型 | psi-mi:"MI:0407"(direct interaction) |
| Source database(s) | 來源的數(shù)據(jù)庫 | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) | 互作識別id | intact:EBI-7121552\ |
| Confidence value(s) | 置信值 | intact-miscore:0.56 |
| Expansion method(s) | 展開方式 | - |
| Biological role(s) interactor A | 生物學(xué)作用 | psi-mi:"MI:0499"(unspecified role) |
| Biological role(s) interactor B | 生物學(xué)作用 | psi-mi:"MI:0499"(unspecified role) |
| Experimental role(s) interactor A | 實(shí)驗(yàn)的作用 | psi-mi:"MI:0498"(prey) |
| Experimental role(s) interactor B | 實(shí)驗(yàn)的作用 | psi-mi:"MI:0496"(bait) |
| Type(s) interactor A | 所屬類型 | psi-mi:"MI:0326"(protein) |
| Type(s) interactor B | 所屬類型 | psi-mi:"MI:0326"(protein) |
| Xref(s) interactor A | 鏈接其他數(shù)據(jù)庫 | ensembl:ENST00000325590\ |
| Xref(s) interactor B | 鏈接其他數(shù)據(jù)庫 | reactome:R-HSA-1660499\ |
| Interaction Xref(s) | - | |
| Annotation(s) interactor A | 注釋 | function:May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton\ |
| Annotation(s) interactor B | 注釋 | comment:"Stoichiometry: 1.0" |
| Interaction annotation(s) | 互作的注釋 | comment:homomint\ |
| Host organism(s) | 宿主的物種 | taxid:-1(in vitro)\ |
| Interaction parameter(s) | - | |
| Creation date | 創(chuàng)建記錄日期 | 2001/1/10 |
| Update date | 更新記錄日期 | 2014/10/16 |
| Checksum(s) interactor A | md5 | rogid:vrgVrVoYr45cUe4X6L/zBAE1RtU9606 |
| Checksum(s) interactor B | md6 | rogid:RA73eMbCn6F7MD0ItxF/V7QbjqM9606 |
| Interaction Checksum(s) | md7 | intact-crc:F4234557A3B54840\ |
| Negative | 是否為負(fù)作用 | FALSE |
| Feature(s) interactor A | 特征 | binding-associated region:626-695(MINT-376295) |
| Feature(s) interactor B | binding-associated region:1063-1070(MINT-376288) | |
| Stoichiometry(s) interactor A | - | |
| Stoichiometry(s) interactor B | - | |
| Identification method participant A | 識別方法 | psi-mi:"MI:0078"(nucleotide sequence identification) |
| Identification method participant B | 識別方法 | psi-mi:"MI:0078"(nucleotide sequence identification) |
