? ? 大家好乘客，我是小燕同學(xué)狐血，今天為大家介紹一篇關(guān)于中藥天然產(chǎn)物羌活醇治療RA的文章淀歇，題目為“The?Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate In?ammation and Arthritis”易核，該文由中國(guó)科學(xué)院王紅艷研究員團(tuán)隊(duì)及王擁軍教授團(tuán)隊(duì)聯(lián)合在2020年9月15日發(fā)表于Cell Reports，JCR分區(qū)：Q1浪默，IF=8.105.
? ? ? ?類風(fēng)濕關(guān)節(jié)炎(RA)是一種慢性自身免疫性疾病牡直，主要影響關(guān)節(jié)，導(dǎo)致疼痛纳决、腫脹和不可逆轉(zhuǎn)的畸形碰逸。開發(fā)口服有效的小分子藥物來(lái)治療風(fēng)濕性關(guān)節(jié)炎一直受到學(xué)者關(guān)注。在這篇文章中阔加，作者主要闡述了中藥單體羌活醇為JAK2/3的抑制劑饵史，及其治療類風(fēng)濕關(guān)節(jié)炎(RA)的作用機(jī)制。
研究思路
·Intraperitoneal or Oral Administration of Notopterol Protects Both DBA/1J and C57/BL6 Mice from Collagen-Induced Arthritis
·Notopterol Inhibits Production of Multiple Pro-in?ammatory Cytokines and Chemokines inTNF-a and Lipopolysaccharides (LPS)-Treated Macrophages
·Notopterol Inhibits JAK-STAT Activation to Attenuate In?ammation
·Notopterol Directly Binds JAK2 and JAK3 to Block LPS/IFN-γ and TNF-a-Induced In?ammation
·Notopterol Binds to the 932/980/981 Sites in the Kinase Domain of JAK2
·Combinationof Notopterol with TNF Blocker (Etanercept) Enhances Therapeutic Ef?cacy in CIA Mice
調(diào)控機(jī)制
