ATAC-seq
Assay for Transposase Accessible Chromatin using sequencing,簡稱ATAC-seq,即是運用測序手段研究轉座酶接近的染色體片段凰慈。核小體包裹的染色體區(qū)域轉座酶是無法接近的,能接近的是開放區(qū)域,用轉座酶講全基因水平的染色體開放區(qū)域切下來測序趣斤。
http://www.biotrainee.com/thread-1218-1-1.html
Hi seq
http://www.nature.com/neuro/journal/v17/n11/box/nn.3816_BX3.html?foxtrotcallback=true
https://www.jove.com/video/1869/hi-c-a-method-to-study-the-three-dimensional-architecture-of-genomes
UMI,unique molecular identifiers
https://cgatoxford.wordpress.com/2015/08/14/unique-molecular-identifiers-the-problem-the-solution-and-the-proof/
batch effect
http://www.molmine.com/magma/global_analysis/batch_effect.html