微孢子蟲影響蜜蜂的行為和生理
微孢子蟲通過改變蜜蜂的生理和行為為了營造個個繁殖有利的環(huán)境
- 破壞蜜蜂中腸的完整性
Dussaubat C, Brunet J-LL, Higes M, Colbourne JK, et al.: Gut Pathology and Responses to the Microsporidium Nosema ceranae in the Honey Bee Apis mellifera. PLoS ONE 2012, 7:e37017
- 改變蜜蜂的能量脅迫
Mayack C, Naug D: Energetic stress in the honey bee Apis mellifera from Nosema ceranae infection. J Invertebr Pathol 2009, 100:185-188
- 抑制蜜蜂的免疫應(yīng)答
Antu′ nez K, Mart?′n-Herna′ ndez R, Prieto L, Meana A, Zunino P, Higes M: Immune suppression in the honey bee (Apis mellifera) following infection by Nosema ceranae (Microsporidia). Environ Microbiol 2009, 11:2284-2290
Aufauvre J, Misme-Aucouturier B, Vigue` s B, Texier C, Delbac F, Blot N: Transcriptome analyses of the honey bee response to Nosema ceranae and insecticides. PLoS ONE 2014, 9:e91686.
Badaoui B, Fougeroux A, Petit F, et al.: RNA-sequence analysis of gene expression from honey bees (Apis mellifera) infected with Nosema ceranae. PLoS ONE 2017, 12:e0173438.
- 改變蜜蜂信息素的產(chǎn)生
Holt HL, Aronstein KA, Grozinger CM: Chronic parasitization by Nosema microsporidia causes global expression changes in core nutritional, metabolic and behavioral pathways in honey bee workers (Apis mellifera). BMC Genomics 2013, 14:799.
Goblirsch M, Huang ZY, Spivak M: Physiological and behavioral changes in honey bees (Apis mellifera) induced by Nosema ceranae infection. PLoS ONE 2013, 8:e58165.
Mayack C, Natsopoulou ME, McMahon DP: Nosema ceranae alters a highly conserved hormonal stress pathway in honey bees. Insect Mol Biol 2015, 24:662-670.
- 縮短蜜蜂的壽命
Goblirsch M, Huang ZY, Spivak M: Physiological and behavioral changes in honey bees (Apis mellifera) induced by Nosema ceranae infection. PLoS ONE 2013, 8:e58165.
Vidau C, Diogon M, Aufauvre J, et al.: Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honey bees previously infected by Nosema ceranae. PLoS ONE 2011, 6:e21550
N. ceranae感染比N. apis感染蜜蜂的死亡率和孢子負(fù)載高
- N. ceranae比N. apis有更高的生物潛伏力
Mart?′n-Herna′ ndez R, Ara′ nzazu Meana, : Effect of temperature on the biotic potential of honey bee microsporidia. Appl Environ Microbiol 2009, 75:2554-2557
- N. ceranae比N. apis更顯著影響蜜蜂的免疫力
- N. ceranae感染比N. apis感染蜜蜂的死亡率更高、更高的寄生蟲負(fù)載
Williams GR, Shutler D, Burgher-MacLellan KL, Rogers REL: Infrapopulation and community dynamics of the parasites Nosema apis and Nosema ceranae, and consequences for honey bee (Apis mellifera) hosts. PLoS ONE 2014, 9:e99465.
N. ceranae影響蜜蜂的生存和免疫必須的代謝通路
- 孢子通過核酸轉(zhuǎn)運從宿主細(xì)胞劫持能量夜矗，依賴宿主提供ATP
Paldi N, Glick E, Oliva M,: Effective gene silencing in a microsporidian parasite associated with honey bee (Apis mellifera) colony declines. Appl Environ Microbiol 2010, 76:5960-5964.
- 卵黃原蛋白對蜜蜂的壽命至關(guān)重要
- 感染孢子蜜蜂的卵黃原蛋白的編碼基因顯著下調(diào)
- N. ceranae通過操縱宿主的行為獲得更多的能量不是通過脂肪體獲取能量
- 抗菌肽基因和膠質(zhì)層基因下調(diào)
- naked cuticle （nkd）基因上調(diào)蒿偎，抑制宿主的免疫基因證實了N. ceranae誘導(dǎo)蜜蜂的免疫應(yīng)答
N. ceranae感染干擾蜜蜂中腸細(xì)胞周期
- buffy促生蛋白編碼基因和BIRC5細(xì)胞凋亡抑制基因家族基因上調(diào)，抑制宿主細(xì)胞凋亡
- N. ceranae逃脫宿主的細(xì)胞凋亡
