"目錄號(hào): HY-13725A
Cell Cycle/DNA DamageAutophagy-
Pirarubicin鹽酸鹽是doxorubicin的類似物胞谭，是Topo II抑制劑。
相關(guān)產(chǎn)品
Cycloheximide-TAK-242-LY294002-3-Methyladenine-(+)-JQ-1-SB 203580-SP600125-U0126-Enzalutamide-Actinomycin D-Olaparib-Doxorubicin hydrochloride-Dorsomorphin dihydrochloride-Mitomycin C-Bortezomib-
生物活性
Description
Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.Target: TopoisomerasePirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
Clinical Trial
Hebei Medical University Fourth Hospital
Breast Cancer
September 2016
Phase 4
RenJi Hospital-Shanghai Pudong Hospital-Shanghai Pudong New Area Gongli Hospital
Intravesical Instillation
January 2017
Phase 2
Second Military Medical University-Zhejiang University-Peking University People's Hospital-Fourth Military Medical University-Xiangya Hospital of Central South University-Institute of Hematology & Blood Diseases Hospital-Union hospital of Fujian Medical University-Harbin Hematology and Oncology Institute-First Affiliated Hospital, Sun Yat-Sen University-Beijing Jishuitan Hospital
Multiple Myeloma
June 2010
Phase 4
Peking University First Hospital
Upper Tract Urothelial Carcinoma-Bladder Recurrence
August 2016
Phase 2
Peking University First Hospital
Bladder Recurrence-Upper Tract Urothelial Carcinoma-Nephroureterectomy
November 2016
Phase 2
307 Hospital of PLA
Breast Neoplasms
July 2009
Phase 3
Xuesong Li-Peking University First Hospital
Upper Tract Urothelial Carcinoma-Bladder Recurrence
September 2015
Phase 2
Ruijin Hospital
ALK-negative Anaplastic Large Cell Lymphoma-Peripherial T Cell Lymphoma,Not Otherwise Specified-Angioimmunoblastic T Cell Lymphoma-Enteropathy Associated T Cell Lymphoma-Hepatosplenic T Cell Lymphoma-Subcutaneous Panniculitis Like T Cell Lymphoma
September 2012
Phase 4
Guangxi Medical University
Hepatocellular Carcinoma
October 2015
Phase 2-Phase 3
Sun Yat-sen University
Hepatocellular Carcinoma
March 2014
Phase 3
Ming Zhao-Sun Yat-sen University
Hepatocellular Carcinoma
October 2014
Phase 3
Japan Adult Leukemia Study Group
Lymphoblastic Leukemia, Acute
September 2002
Phase 2
University of Maryland-National Institute on Drug Abuse (NIDA)
Cocaine Use
October 2012
Phase 1
University of Maryland-National Institute on Drug Abuse (NIDA)
Cocaine Use
September 2014
Phase 2
Human Development Research Foundation, Pakistan-Duke University-University of Liverpool
Maternal Depression
March 2016
University of Liverpool-National Institute of Mental Health (NIMH)-London School of Hygiene and Tropical Medicine
Unipolar Depression
October 2014
Phase 2-Phase 3
London School of Hygiene and Tropical Medicine-National Institute of Mental Health (NIMH)-University of Liverpool
Unipolar Depression
October 2014
Phase 2-Phase 3
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References
