1.常用門戶:
美國國家生物技術信息中心(NCBI):https://www.ncbi.nlm.nih.gov
歐洲生物信息學研究所(EMBL-EBI):https://www.ebi.ac.uk
UCSC Genome:http://genome.ucsc.edu
國際生物信息學動態(tài)及會議:http://www.bioinformatics.org
SeqAnswer 國際生物信息技術問答論壇:http://seqanswers.com
Biostar生物信息技術問答論壇:https://www.biostars.org
2.DNA和RNA數(shù)據(jù)庫
GeneBank:https://www.ncbi.nlm.nih.gov
EMBL:https://www.ebi.ac.uk
DDBJ:https://www.ddbj.nig.ac.jp/index-e.html
RefSeq:https://www.ncbi.nlm.nih.gov/refseq/
參考序列數(shù)據(jù)庫收集了從病毒口四、細菌到真核生物等主要生物的核酸序列(DNA、RNA)及其蛋白質常產物
3.蛋白質數(shù)據(jù)庫
a.蛋白質序列數(shù)據(jù)庫
UniProt:https://www.uniprot.org
PIR:https://proteininformationresource.org
b.蛋白質功能域數(shù)據(jù)庫
InterPro:http://www.ebi.ac.uk/interpro/
ExPASy:https://prosite.expasy.org
SMART:http://smart.embl.de
iProClass:https://proteininformationresource.org/pirwww/dbinfo/iproclass.shtml
ProDom:http://prodom.prabi.fr/prodom/current/html/form.php
PRINTS:http://130.88.97.239/PRINTS/index.php
c.蛋白質結構數(shù)據(jù)庫
RCSB PDB:http://www.rcsb.org
SCOP:http://scop.mrc-lmb.cam.ac.uk
PDBe:https://www.ebi.ac.uk/pdbe/
PDBj-BMRB:https://bmrbdep.pdbj.org
d.蛋白質組學數(shù)據(jù)庫
ConsensusPathDB:http://cpdb.molgen.mpg.de
PRIDE:https://www.ebi.ac.uk/pride/archive
CORUM:https://mips.helmholtz-muenchen.de/corum/
World-2DPAGE:https://world-2dpage.expasy.org/swiss-2dpage/
4.代謝途徑與細胞調控數(shù)據(jù)庫
KEGG:https://www.genome.jp/kegg/
Enzyme:https://www.brenda-enzymes.org
IMP:http://imp.princeton.edu
Plantcy:https://www.plantcyc.org
MANET:https://manet.illinois.edu
BioSystems:https://www.ncbi.nlm.nih.gov/biosystems
Pathguide:http://www.pathguide.org
MapMan:http://mapman.gabipd.org/web/guest
Microme:https://www.microme.eu
SMPDB:https://smpdb.ca
5.非編碼RNA數(shù)據(jù)庫
miRBase:http://www.mirbase.org
AnnoLnc2:http://annolnc.gao-lab.org
piRNABank:http://pirnabank.ibab.ac.in
GtRNAdb:http://gtrnadb.ucsc.edu
Silva:https://www.arb-silva.de
LNCipedia:https://lncipedia.org/db
LncRNAWiki:http://lncrna.big.ac.cn/index.php/Main_Page
NONCODE:http://www.noncode.org
LncRBase:http://bicresources.jcbose.ac.in/zhumur/lncrbase/
siRNA:http://web.mit.edu/sirna/
circBase:http://www.circbase.org
6.基因功能注釋數(shù)據(jù)庫
GO:http://geneontology.org
KEGG:https://www.genome.jp/kegg/
DAVID:https://david.ncifcrf.gov
GOrilla:http://cbl-gorilla.cs.technion.ac.il
BioGPS:http://biogps.org/#goto=welcome
強大的基因和蛋白表達注釋平臺
7.與人相關據(jù)庫
GeneCard:https://www.genecards.org/
自動整合125個數(shù)據(jù)庫,包含基因組、轉錄組、蛋白組、遺傳龄糊、臨床和功能信息的龐大人基因組數(shù)據(jù)庫
GENCODE:https://www.gencodegenes.org/
人和小鼠基因組中的所有基因特征進行識別和分類,并釋放這些注釋以利于生物醫(yī)學研究和基因組解釋
mBiobank:http://www.mbiobank.com/
中國代謝解析計劃
Genecard:https://www.genecards.org
提供基因組募疮,蛋白質組炫惩,轉錄,遺傳和功能上所有已知和預測的人類基因
ConsensusPathDB:http://consensuspathdb.org
分子功能互作數(shù)據(jù)庫阿浓,基于32個公共數(shù)據(jù)庫他嚷,整合了人類蛋白質相互作用,遺傳相互作用信號芭毙,代謝筋蓖,基因調控和藥物 - 靶標相互作用的信息
Human protein atlas:https://www.proteinatlas.org
人體蛋白在細胞、組織稿蹲、病理條件下的表達
GTEx:https://www.genome.gov/Funded-Programs-Projects/Genotype-Tissue-Expression-Project
UCSC:http://genome.ucsc.edu
1000Genomes:https://www.internationalgenome.org
2008年1月啟動的項目扭勉,對來自不同種族群體的一千多名匿名參與者的基因組進行了分析,并將數(shù)據(jù)公布于眾
Personal Genome Project:https://www.personalgenomes.org
來自世界各地的100,00名志愿者的人類基因組計劃
OMIM:https://omim.org
一個管理人類基因和人類遺傳疾病特征的數(shù)據(jù)庫
TCGA:https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga
Human Epigenome Project:https://www.epigenome.org
Epifactors:https://epigenie.com/epigenetic-tools-and-databases/
MethDB:http://www.methdb.de
Methycancer:http://methycancer.psych.ac.cn/
Oncomine:https://www.oncomine.org/resource/login.html
HUPO:https://hupo.org
Human protein atlas:https://www.proteinatlas.org
dbGaP:https://www.ncbi.nlm.nih.gov/gap/
人基因型與表型互作數(shù)據(jù)庫
8.模式生物數(shù)據(jù)庫
a.植物
Phytozome:https://phytozome.jgi.doe.gov/pz/portal.html
PLANTGDB:http://www.plantgdb.org
Ensembplants:http://plants.ensembl.org/index.html
TAIR:https://www.arabidopsis.org
最全的擬南芥資源數(shù)據(jù)庫
Legume Information System (LIS):https://legumeinfo.org
豆科植物的基因組數(shù)據(jù)庫
BRAD:http://brassicadb.org/brad/
Sol genomics:https://www.solgenomics.net
RGAP:http://rice.plantbiology.msu.edu
RAP-DB:https://rapdb.dna.affrc.go.jp
Gramene:http://www.gramene.org
MAIZECDB:https://www.maizegdb.org
b.鼠
Rat Genome Database (RGD):https://rgd.mcw.edu/
大鼠基因組數(shù)據(jù)庫
MPD:Mouse Phenome Database:https://phenome.jax.org
Mouse genome:http://www.informatics.jax.org
可以比較小鼠和人類基因組的區(qū)別苛聘;查找基因功能及敲除某個基因后導致的表型涂炎;人類-小鼠相關疾仓揖邸;基因表達等
Mouse Genome Database(MGD):http://www.nervenet.org/main/dictionary.html
MGD數(shù)據(jù)庫是整合了國際上實驗室小鼠生物數(shù)據(jù)的資源庫唱捣,提供小鼠相關的基因組两蟀、綜合遺傳等信息
Mouse Genetics and Genomics Software and Tools:http://mouse.cs.ucla.edu/
Mouse Genomes Project:https://www.sanger.ac.uk/science/data/mouse-genomes-project
GENCODE:https://www.gencodegenes.org/
人和小鼠基因組中的所有基因特征進行識別和分類,并釋放這些注釋以利于生物醫(yī)學研究和基因組解釋
c.動物
UCSC genome:http://genome.ucsc.edu
Ensemblmetazoa:http://metazoa.ensembl.org/index.html
FlyBase:http://flybase.org
模式生物果蠅的基因組數(shù)據(jù)庫
Zebrafish genome:http://zfin.org
斑馬魚的基因組數(shù)據(jù)庫
Xenbase:http://www.xenbase.org/entry/
Wormbase:https://wormbase.org//#012-34-5
Nematode:http://nematode.net/NN3_frontpage.cgi
模式生物非洲爪蟾(Xenopus tropicalis)和非洲爪蟾(Xenopus laevis)的基因組數(shù)據(jù)庫
Wormbase:https://wormbase.org/#012-34-5
關于線蟲模式生物秀麗隱桿線蟲的生物學和基因組在線生物數(shù)據(jù)庫