Cancers 2021, 13, 1732.
Simple Summary: Anthracyclines are a class of chemotherapeutics that are an essential component of many treatment regimens for solid and blood tumors. Doxorubicin (DOX), an anthracycline is broadly considered the most active single agent available for many cancers. However, effective use of anthracyclines is limited due to the possibility of cardiotoxicity, thus causing restrictions on treatment options for treatable cancers. Our studies indicate the SP/NK1R system as a promising novel target and use of NK1R antagonists as a translational tool for prevention of chemotherapy-associated cardiotoxicity in cancer.
簡(jiǎn)單總結(jié)：蒽環(huán)類(lèi)化療藥是許多實(shí)體瘤和血液瘤的許多治療方案中必不可少的成分。阿霉素（Doxorubicin（DOX））可治療多種癌癥蝶念，被認(rèn)為是最活躍的化療藥物之一贺拣。但是熬拒，蒽環(huán)類(lèi)藥物的使用常常因?yàn)槠湫呐K毒性的可能而受到限制矗愧，從而導(dǎo)致無(wú)法用它治療那些本可治療的癌癥御吞。我們的研究表明P物質(zhì) / NK-1受體系統(tǒng)作為一個(gè)新的治療靶點(diǎn)很有希望儿子，用于為腫瘤患者預(yù)防化療相關(guān)的心臟毒性瓦哎。
阿瑞匹坦，不止具有預(yù)防化療引起的惡心嘔吐的作用柔逼，而且還表現(xiàn)出廣譜的抗腫瘤作用蒋譬。如今又有望對(duì)治化療藥物的心臟毒性。
來(lái)自MD Anderson 腫瘤中心的研究結(jié)果
