"目錄號: HY-15257A
Mavoglurant racemate 是 mavoglurant 的外消旋體剧罩。Mavoglurant 是一種新穎的栓拜，非競爭性的 mGlu5 受體拮抗劑。
相關(guān)產(chǎn)品
CTEP-LY341495-LY354740-LY404039-RG7090-Mavoglurant-MPEP Hydrochloride-Dipraglurant-Topiramate-JNJ-40411813-L-Glutamine-FITM-JNJ16259685-MTEP hydrochloride-(S)-MCPG-
生物活性
Description
Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.
In Vitro
For antagonistic activity, (?)-mavoglurant, the (?)-enantiomer shows IC50of 0.11 μM and 0.03 μM (Ca2+and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1].
References
