Ombitasvir

Anti-infection Metabolic Enzyme/Protease-

Ombitasvir ?????????HCV NS5A??????????????? HCV ????????? 1-5 ??? 6a ???EC50???????????? 0.82-19.3 pM ??? 366 pM???

HCV HCV Protease

相關(guān)產(chǎn)品

Asunaprevir-PSI-7977-Simeprevir-Daclatasvir-Paritaprevir-Telaprevir-Boceprevir-Ledipasvir-MK-5172-Elbasvir-ABT-333-Ribavirin-R-1479-Balapiravir-Artemisinin-

生物活性

Description

Ombitasvir is a potent inhibitor of thehepatitis C virus protein NS5A, withEC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

IC50& Target

EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a)[1]

In Vitro

Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively[1]. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir[2].

Clinical Trial

NCT01704755

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection-Compensated Cirrhosis

October 2012

Phase 3

NCT01911845

AbbVie

Chronic Hepatitis C Infection-Chronic Hepatitis C

April 2013

Phase 2

NCT01674725

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

August 2012

Phase 3

NCT02534870

AbbVie

Healthy Volunteer

September 2015

Phase 1

NCT01672983

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

July 2012

Phase 2

NCT02023112

AbbVie

Hepatitis C Virus

January 2014

Phase 3

NCT01314261

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C-Hepatitis C Virus (HCV) Infection

March 2011

Phase 2

NCT02052362

AbbVie

Absolute Bioavailability

January 2014

Phase 1

NCT01563536

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

February 2012

Phase 2

NCT02517528

AbbVie

Chronic Hepatitis C Virus

July 2015

Phase 3

NCT01685203

AbbVie (prior sponsor, Abbott)-AbbVie

Hepatitis C, Chronic

August 2012

Phase 2

NCT02167945

AbbVie

Chronic Hepatitis C Virus (HCV) Infection Genotype 1

June 12, 2014

Phase 3

NCT02219490

AbbVie

Chronic Hepatitis C Virus (HCV) Infection Genotype 1

October 30, 2014

Phase 3

NCT02517515

AbbVie

Chronic Hepatitis C Virus

July 16, 2015

Phase 3

NCT01767116

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

December 2012

Phase 3

NCT02023099

AbbVie

Chronic Hepatitis C Infection

December 2013

Phase 3

NCT01833533

AbbVie

Chronic Hepatitis C Infection

March 2013

Phase 3

NCT01716585

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

November 2012

Phase 3

NCT01715415

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

November 2012

Phase 3

NCT01181427

Abbott

HCV Infection

August 2010

Phase 1

NCT01458535

AbbVie (prior sponsor, Abbott)-AbbVie

Hepatitis C Virus

September 2011

Phase 2

NCT01464827

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C-Hepatitis C (HCV)-Hepatitis C Genotype 1

October 2011

Phase 2

NCT01939197

AbbVie

Hepatitis C Virus Infection-Human Immunodeficiency Virus Infection-Chronic Hepatitis C-Compensated Cirrhosis and Non-cirrhotics

August 2013

Phase 3

NCT01854528

AbbVie

Chronic Hepatitis C Infection

June 2013

Phase 3

NCT01854697

AbbVie

Chronic Hepatitis C Infection

March 2013

Phase 3

NCT01782495

AbbVie

Chronic Hepatitis C Infection

February 25, 2013

Phase 2

NCT01609933

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C-Hepatitis C (HCV)-Hepatitis C Genotype 1

December 18, 2012

Phase 2

NCT01773070

AbbVie (prior sponsor, Abbott)-AbbVie

Hepatitis C

June 2013

Phase 3

NCT01995071

AbbVie

Chronic Hepatitis C-Hepatitis C Virus-Compensated Cirrhosis

November 2013

Phase 2

NCT02734173

Ottawa Hospital Research Institute-AbbVie

Hepatitis C

July 2015

Phase 4

NCT01704755

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection-Compensated Cirrhosis

October 2012

Phase 3

NCT01911845

AbbVie

Chronic Hepatitis C Infection-Chronic Hepatitis C

April 2013

Phase 2

NCT01674725

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

August 2012

Phase 3

NCT02534870

AbbVie

Healthy Volunteer

September 2015

Phase 1

NCT01672983

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

July 2012

Phase 2

NCT02023112

AbbVie

Hepatitis C Virus

January 2014

Phase 3

NCT01314261

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C-Hepatitis C Virus (HCV) Infection

March 2011

Phase 2

NCT02052362

AbbVie

Absolute Bioavailability

January 2014

Phase 1

NCT01563536

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

February 2012

Phase 2

NCT02517528

AbbVie

Chronic Hepatitis C Virus

July 2015

Phase 3

NCT01685203

AbbVie (prior sponsor, Abbott)-AbbVie

Hepatitis C, Chronic

August 2012

Phase 2

NCT02167945

AbbVie

Chronic Hepatitis C Virus (HCV) Infection Genotype 1

June 12, 2014

Phase 3

NCT02219490

AbbVie

Chronic Hepatitis C Virus (HCV) Infection Genotype 1

October 30, 2014

Phase 3

NCT02517515

AbbVie

Chronic Hepatitis C Virus

July 16, 2015

Phase 3

NCT01767116

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

December 2012

Phase 3

NCT02023099

AbbVie

Chronic Hepatitis C Infection

December 2013

Phase 3

NCT01833533

AbbVie

Chronic Hepatitis C Infection

March 2013

Phase 3

NCT01716585

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

November 2012

Phase 3

NCT01715415

AbbVie (prior sponsor, Abbott)-AbbVie

Chronic Hepatitis C Infection

November 2012

Phase 3

最后編輯于：2017.12.11 15:08:46

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Ombitasvir

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