"目錄號: HY-14427
4E1RCat能抑制eIF4E與eIF4G的相互作用及eIF4E與4E-BP1的相互作用，可抑制eIF4G和eIF4E的結(jié)合，IC50為3.2 μM。
Eukaryotic Initiation Factor (eIF)
相關(guān)產(chǎn)品
生物活性
Description
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.IC50 value: 3.2 uM [1]Target: eIF4E/eIF4G inhibitorIn in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.
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