"目錄號(hào): HY-14178
MAPK/ERK PathwayStem Cell/Wnt-
VX-11e 是一種高效的，具有選擇性的攒巍，可口服的ERK抑制劑，Ki值 < 2 nM荒勇。
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SCH772984-GDC-0994-XMD8-92-TIC10-FR 180204-Tauroursodeoxycholate Sodium-Tomatidine-VRT752271-APS-2-79-Corynoxeine-Astragaloside IV-DEL-22379-XMD17-109-ERK5-IN-1-Mogrol-
生物活性
Description
VX-11e is a potent, selective, and orally bioavailable inhibitor ofERKwithKi< 2 nM.
In Vitro
VX-11e?is active in the HT29 cell proliferation assay (IC50=48 nM)[1].
In Vivo
VX-11e is orally bioavailable in both rat and mice[1]. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition[2].
References
