"目錄號(hào): HY-14824
Membrane Transporter/Ion ChannelNeuronal Signaling-
ABT 894是nAChR的激動(dòng)劑蝌箍，是一種有潛力的非興奮劑來治療注意力缺陷癥庶溶。
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L-Nicotine-PNU-282987-Vinblastine-Carbamoylcholine chloride-PNU-120596-Pancuronium dibromide-Aniracetam-Catharanthine-Varenicline-Hexamethonium Bromide-Vecuronium bromide-GTS-21 dihydrochloride-Tebanicline hydrochloride-A-867744-Adiphenine hydrochloride-
生物活性
Description
ABT 894 is an agonist ofnicotinic acetylcholine receptor (nAChR), used as a potential non-stimulant treatment for attention-deficit/hyperactivity disorder (ADHD).
In Vitro
ABT-894 is more potent than ABT-089 at both receptor subtypes, with Kivalues of 1.9 nM for125I-α-conotoxinMII binding and of 1.3 nM for125I-epibatidine binding[1].
In Vivo
ABT-894 (0.001 to 0.10 mg/kg, p.o.) produces significant reductions in LIDs compared to vehicle monkey[1]. ABT-894 (0.1 mg/kg) does not decrease LIDs in monkeys with severe nigrostriatal damage[2].
References
