無意中看到一篇關(guān)于IC/BPS的非腫瘤文章赤惊，還有臨床驗(yàn)證寝受，非常值得模仿妻熊。
Title: Bruton tyrosine kinase (BTK) may be a potential therapeutic target for interstitial cystitis/bladder pain syndrome
PMID：36069808
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所用數(shù)據(jù)集：GSE11783灶轰，GSE57560羡洁，GSE621
背景知識(shí)：肥大細(xì)胞異称渎ⅲ活化和趨化是IC/BPS的主要病理機(jī)制之一苛蒲。（HMC-1肥大細(xì)胞)
同類型疾病：glandular cystitis/Cystitis glandularis腺性膀胱炎
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文章思路：
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加分項(xiàng)1
感覺文章中加分項(xiàng)是臨床驗(yàn)證部分绿满，作者選取了10對(duì)IC/BPS病人標(biāo)本+10對(duì)正常膀胱組織（來自膀胱癌病人）撤防。
Fig.4 -
加分項(xiàng)2
作用最后在HMC-1肥大細(xì)胞中敲低目標(biāo)基因BTK，進(jìn)行CCK-8、遷移和肥大細(xì)胞脫粒指標(biāo)檢測(cè)寄月。
Fig.5
- 彩蛋→Q:那么我們應(yīng)該如何研究IC/BPS呢辜膝？
當(dāng)然可以建立動(dòng)物模型的，類型這篇文章The NLRP3 Inflammasome Inhibitor Dapansutrile Attenuates Cyclophosphamide-Induced Interstitial Cystitis.(PMID：35720309)
參考鏈接:
- Bruton tyrosine kinase (BTK) may be a potential therapeutic target for interstitial cystitis/bladder pain syndrome(PMID:36069808)
- WGCNA and molecular docking reveal key hub genes and potential natural inhibitor in interstitial cystitis/bladder pain syndrome(PMID：35333927)
- Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion(PMID：32575815)
