JACS
COLOR CHANGES TRACK REACTION’S PROGRESS
色彩改變軌道反應的進展
?Light-activated dienes based on o-methylbenzaldehydes (o MBAs) are tried-and-true starting materials for making polymers and nanoparticles, and they are used in 3D laser writing. Unlike other light-triggered chemical reagents, these dienes do not flfluoresce during a reaction’s progress. Although this solves one problem flfluorescence during the reaction can degrade the quality of the reaction productskeeping track of the formation of intermediate species and fifinal product is more diffiffifficult without some sort of visual feedback. Now, Anja Goldman, James Blinco, Christopher Barner-Kowollik, and co workers have developed a synthesis in which light absorption and emission shift in wavelength and intensity over the course of the reaction, signaling the formation of intermediate species and the flfluorescent fifinal products (DOI: 10.1021/ jacs.0c02002).
基于鄰甲基苯甲醛（o MBA）的光活化二烯是用于制造聚合物和納米粒子的可靠原料洒忧，它們被用于3D激光書寫微饥。與其他光觸發(fā)化學試劑不同咒程，這些二烯在反應過程中不會發(fā)出熒光咙鞍。盡管這解決了一個問題，但反應過程中的熒光會降低反應產物的質量袖牙，并跟蹤中間產物的形成，而最終產物則很難獲得某種視覺反饋【顺現在鞭达，安雅·戈德曼（Anja Goldman），詹姆斯·布林科（James Blinco）皇忿，克里斯托弗·巴納·科沃里克（Christopher Barner-Kowollik）及其同事已經開發(fā)出一種合成物畴蹭，該合成物在反應過程中光吸收和發(fā)射在波長和強度上發(fā)生位移，這表明中間物質和熒光終產物的形成（ DOI：10.1021 / jacs.0c02002）鳍烁。
The researchers used several innovative and non-trivial? chemical transformations to make their starting materials,? which react with each other under illumination with a UV or? blue LED light source. The reaction takes place in an acidic? aqueous solution (pH 4.2) at ambient temperature. No catalyst? is required, which avoids byproducts that would make these? materials unsuitable for biological applications. This synthesis? method could be used to produce organic dyes and probe? molecules, and in similar applications.? Nancy McGuire Ph.D.?
研究人員使用了幾種創(chuàng)新的叨襟，非常重要的化學轉化方法來制造其起始原料，這些原料在紫外或藍色LED光源的照射下會相互反應幔荒。反應在環(huán)境溫度下在酸性水溶液（pH 4.2）中進行糊闽。不需要催化劑梳玫，可以避免副產物，這些副產物會使這些材料不適合生物應用墓怀。這種合成方法可用于生產有機染料和探針分子汽纠，并且可用于類似的應用中。南峡模·麥奎爾（Nancy McGuire）博士■
UNRAVELING THE MECHANISM FROM DIAZOALKANES TO CARBENES
Mechanistic understanding of chemical reactions can be? powerful, giving scientists the ability to predict the outcome? of unattempted reactions with confifidence. A detailed? exploration of the mechanism can even be exploited in clever? applications within a variety of fifields. Although diazoalkanes? have proven to be versatile building blocks for the photo? chemical formation of carbenes, a mechanistic study into how? the process takes place remains unprecedented. Interpreting? the excited-state transformations will open up the selective? control of these reactions as well as new chemistry to? researchers.? Recent work by Nikola Basaric, Nada Doslic, and co-workers? has set out to do just this with an approach that synergistically? combines experimental data with computer simulations (DOI:? 10.1021/jacs.0c02221).
