"目錄號: HY-13648
Incyclinide (CMT-3, COL-3) 是一種基質(zhì)金屬蛋白酶 (MMP) 抑制劑猫态，誘導細胞外基質(zhì)降解，抑制血管生成仔役，腫瘤生長和侵襲以及轉(zhuǎn)移间护。
相關(guān)產(chǎn)品
Doxycycline hyclate-GM6001-T-5224-SB-3CT-Marimastat-Batimastat-TAPI-1-Edaravone-TAPI-2-Astragaloside IV-CTS-1027-NSC 405020-Arctigenin-CL-82198-S-methyl-KE-298-
生物活性
Description
Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
In Vitro
Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture.? Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells[1]. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%[2].
In Vivo
Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix[3].
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