1钓试、安裝pywin32
pip install -i https://pypi.tuna.tsinghua.edu.cn/simple pywin32
2、代碼

import win32con
import win32gui
import win32api
import time
import random
import subprocess

def test1():
    print('開始了')
    # 找出窗體編號(hào)    
    subprocess.Popen(r"C:\Program Files (x86)\Foxit Software\Foxit PhantomPDF\FoxitPhantomPDF.exe")
    time.sleep(1)
    hwnd =win32gui.GetForegroundWindow()    
    print(hwnd)
    left, top, right, bottom = win32gui.GetWindowRect(hwnd)
    #找到“打開”按鈕的坐標(biāo)位置，單擊（暫不用此方法，直接發(fā)送快捷鍵ctrl+O帅霜，效果一樣）
    #win32api.SetCursorPos([left+40,top+20])
    #win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP | win32con.MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0)
    
    # 設(shè)置為當(dāng)前活動(dòng)窗口
    win32gui.SetForegroundWindow(hwnd)
    
    # 按下ctrl+O
    win32api.keybd_event(win32con.VK_CONTROL, 0, 0, 0)
    win32api.keybd_event(ord('O'), 0, 0, 0)
    win32api.keybd_event(ord('O'), 0, win32con.KEYEVENTF_KEYUP, 0)
    win32api.keybd_event(win32con.VK_CONTROL, 0, win32con.KEYEVENTF_KEYUP, 0)
    time.sleep(1)
    # 獲取打開彈出框
    hwDlg= win32gui.FindWindow("#32770","打開")     
    print(hwDlg)
    #輸入文件名
    a1 = win32gui.FindWindowEx(hwDlg,None,"ComboBoxEx32",None)
    a2 = win32gui.FindWindowEx(a1,None,"ComboBox",None)    
    hwnd_filename = win32gui.FindWindowEx(a2,None,"Edit",None)
    win32gui.SendMessage(hwnd_filename, win32con.WM_SETTEXT, None, "F:\\py\\win32gui\\測(cè)試文件\\百科圖解野外求生技巧.pdf")

    # 點(diǎn)擊打開
    hwnd_save = win32gui.FindWindowEx(hwDlg,None,"Button",None)
    win32gui.PostMessage(hwnd_save, win32con.WM_KEYDOWN, win32con.VK_RETURN, 0)
    win32gui.PostMessage(hwnd_save, win32con.WM_KEYUP, win32con.VK_RETURN, 0)
    time.sleep(3)

    #點(diǎn)擊轉(zhuǎn)換按鈕
    win32api.SetCursorPos([left+140,top+40])    
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP | win32con.MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0)
    time.sleep(0.1)
    win32api.SetCursorPos([left+470,top+90])    
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP | win32con.MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0)
    time.sleep(0.1)
    win32api.SetCursorPos([left+470,top+135])    
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP | win32con.MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0)    
    #     
    # 獲取另存為
    time.sleep(3)
    hwDlg= win32gui.FindWindow("#32770","另存為")     
    print(hwDlg)
    #輸入文件名
    a1 = win32gui.FindWindowEx(hwDlg,None,"DUIViewWndClassName",None)
    a2 = win32gui.FindWindowEx(a1,None,"DirectUIHWND",None)    
    a3 = win32gui.FindWindowEx(a2,None,"FloatNotifySink",None)    
    a4 = win32gui.FindWindowEx(a3,None,"ComboBox",None)        
    hwnd_filename = win32gui.FindWindowEx(a4,None,"Edit",None)
    win32gui.SendMessage(hwnd_filename, win32con.WM_SETTEXT, None, "F:\\py\\win32gui\\測(cè)試文件\\百科圖解野外求生技巧2.docx")
    time.sleep(0.2)
    # 點(diǎn)擊保存
    hwnd_save = win32gui.FindWindowEx(hwDlg,None,"Button",None)
    win32gui.PostMessage(hwnd_save, win32con.WM_KEYDOWN, win32con.VK_RETURN, 0)
    win32gui.PostMessage(hwnd_save, win32con.WM_KEYUP, win32con.VK_RETURN, 0)
    time.sleep(3)    

    # 按下ctrl+shit+W 關(guān)閉所有頁簽
    win32api.keybd_event(win32con.VK_CONTROL, 0, 0, 0)
    win32api.keybd_event(win32con.VK_SHIFT, 0, 0, 0)
    win32api.keybd_event(ord('W'), 0, 0, 0)
    win32api.keybd_event(ord('W'), 0, win32con.KEYEVENTF_KEYUP, 0)
    win32api.keybd_event(win32con.VK_SHIFT, 0, win32con.KEYEVENTF_KEYUP, 0)    
    win32api.keybd_event(win32con.VK_CONTROL, 0, win32con.KEYEVENTF_KEYUP, 0)    
    # 隱藏窗體    
    # win32gui.ShowWindow(hwnd,win32con.SW_HIDE)
    #     
    # 顯示窗體
    # win32gui.ShowWindow(hwnd,win32con.SW_SHOW)
   
def main():
    test1()


if __name__ == '__main__':
    main()