長非編碼RNA（lncRNA）是功能性非翻譯分子，長度超過200個核苷酸科乎，具有多種作用，例如染色質(zhì)修飾茅茂，轉(zhuǎn)錄調(diào)控和蛋白質(zhì)構(gòu)象變化。
其實LncRNA并非嚴格意義的非編碼RNA,越來越多的LncRNA被發(fā)現(xiàn)有sORF,編碼少于100個氨基酸的微肽空闲。
植物中的LncRNA數(shù)據(jù)庫有：
GreeNC #包含常用的植物LncRNA的fasta序列，可以直接下載到本地使用逗噩。
[PlncRNADB][http://bis.zju.edu.cn/PlncRNADB/index.php] 支持物種少悔常，擬南芥、玉米矫户、毛果楊
LncRNA鑒定工具的綜述 2020
LncRNA的預(yù)測：
植物LncRNA鑒定專用工具
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RNAplonc T.C. Negri, W.A.L. Alves, P.H. Bugatti, P.T.M. Saito, D.S. Domingues, A.R. Paschoal
Pattern recognition analysis on long noncoding RNAs: a tool for prediction in plants
Briefings in Bioinformatics’, 20 (2019), pp. 682-689 - CREMA C.M.A. Simopoulos, E.A. Weretilnyk, G.B. Golding
Prediction of plant lncRNA by ensemble machine learning classifiers
BMC Genomics, 19 (2018), p. 316 - PLIT S. Deshpande, J. Shuttleworth, J. Yang, S. Taramonli, M. England
PLIT: An alignment-free computational tool for identification of long non-coding RNAs in plant transcriptomic datasets
Comput Biol Med, 105 (2019), pp. 169-181
其他的LncRNA鑒定工具
- LGC（2019年發(fā)表）
LGC用于預(yù)測LncRNA 動植物都可以使用
LGC的文章表明LGC的預(yù)測的魯棒性和準確度要高于基于比對的算法
LGC基于ORF長度和GC含量之間的特征關(guān)系，與蛋白質(zhì)編碼RNA相比皆辽，來預(yù)測LncRNA - CPC Kong L. et al. (2007) CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res., 35, W345–W349. (Web Server issue).
- COME Hu L. et al. (2017) COME: a robust coding potential calculation tool for lncRNA identification and characterization based on multiple features. Nucleic Acids Res., 45, e2.
- PhyloCSF Lin M.F. et al. (2011) PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions. Bioinformatics, 27, i275–i282.
簡單的LncRNA測序分析文章
2020《BMC genomics》LncRNA
LncRNA和miRNA相互作用 綜述 Veneziano D., Marceca G.P., Di Bella S., Nigita G., Distefano R., Croce C.M. (2019) Investigating miRNA–lncRNA Interactions: Computational Tools and Resources. In: Laganà A. (eds) MicroRNA Target Identification. Methods in Molecular Biology, vol 1970. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9207-2_14
